Rab10 and Arhgef7 interact to promote axon extension by linking vesicle supply and exocytosis

Rab10–Arhgef7 interaction promotes axon extension by stimulating Arhgef7 activity on PPVs, enabling exocyst-dependent exocytosis through Cdc42b in early neuronal differentiation.

• Why it matters: Axon elongation needs plasma-membrane expansion, but how increased vesicle delivery into a nascent axon is coupled to vesicle insertion via exocytosis is not fully understood.
• What they did: In early neuronal differentiation, Rab10 was shown to interact with Arhgef7, where Rab10 increases Arhgef7’s GEF activity on PPVs for Cdc42b, promoting exocyst-dependent exocytosis and axon extension.
• The result: Increasing vesicle transport in unpolarized neurons is sufficient to extend additional axons, supporting a model where higher PPV supply is linked to their exocytosis via Rab10–Arhgef7.

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