Temperature-dependent Fano resonance in Microtubules and Tubulin investigated with Spontaneous Raman Spectroscopy

Fano resonance asymmetry (q<5) persists at room and physiological temperatures in dry-powder microtubules and tubulin for specific vibrational modes.

• Why it matters: Molecular bond vibrations that show Fano-type line shapes could reveal temperature-dependent interactions in microtubule-based structures, but this behavior is not well characterized across cryogenic to physiological conditions.
• What they did: Raman spectra were measured on dry powder samples of microtubules and constituent tubulin from 77 K up to room temperature and 310 K, scanning for Fano resonance asymmetry in vibrational modes.
• The result: Nontrivial Fano resonances with q<5 were observed at room and 310 K for selected vibrational modes, indicating temperature-dependent persistence in these systems.

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