Endothelial protein C receptor is an entry receptor for Langya virus

Langya virus uses human endothelial protein C receptor (EPCR) as an entry receptor, with its tetrameric G attachment glycoprotein binding EPCR avidly.

• Why it matters: Parahenipaviruses like Langya virus are poorly understood and lack approved vaccines or therapeutics, despite pandemic potential and broad geographic distribution.
• What they did: The study mapped how Langya virus G recognizes EPCR and tested whether human and shrew EPCR orthologs support cell entry of Langya virus and Mojiang pseudoviruses.
• The result: The findings show EPCR ortholog usage across human and shrew receptors and enable prediction of EPCR utilization in newly discovered Parahenipaviruses for surveillance and countermeasure design.

AI summary of the abstract · may contain errors · not medical advice · read the paper.