Preserving Nanotherapy-Induced Allogeneic Murine Islet Graft Tolerance During Distal Methicillin-Resistant Staphylococcus aureus Skin Infection

Rapamycin-loaded polymersomes preserve neutrophil antibacterial function and post-MRSA recovery, but a distal MRSA skin infection reduces rPS-treated murine islet allograft recipient survival by ~43%.

• Why it matters: Short-course tolerogenic regimens must remain effective during hospital-acquired infections that transplant recipients commonly face, yet how distal inflammation impacts graft tolerance is unclear.
• What they did: In mice with murine islet allografts, rPS was tested during Methicillin-resistant Staphylococcus aureus (MRSA) skin infection; immune readouts included neutrophil activity, IL-6 within 24h, TNF-α, and neutrophilia at 13 days, with survival and glucose-stimulated insulin responsiveness measured.
• The result: MRSA infection triggered IL-6 and later TNF-α with neutrophilia, eroding allograft acceptance; adding a single dose of methylprednisolone reduced IL-6 and TNF-α and nearly doubled survival to 80% without changing neutrophilia.

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