Pervasive chromothripsis drives pleural mesothelioma to impact gene function and patient survival

Chromothripsis is present in 74% of pleural mesothelioma tumours and is linked to significantly worse patient survival, alongside frequent CNA hotspots.

• Why it matters: Pleural mesothelioma shows high structural complexity, but the range of genomic variants and how they affect gene function and outcomes remains unclear.
• What they did: The study profiled tumour genome and transcriptome in parallel across a large cohort (N=443), mapping copy number alterations and complex rearrangements.
• The result: Chromothripsis contributes to CNA hotspots deleting tumour suppressor genes such as CDKN2A, NF2, and BAP1, and its presence predicts poorer survival.

AI summary of the abstract · may contain errors · not medical advice · read the paper.