Transdiagnostic Functional Brain Alterations Across Familial and Phenotypic Risk Samples: A Meta-Analysis

High-risk samples for psychosis, mood, and anxiety show shared increased task-related activation in the left lateral prefrontal cortex (k = 319, p < 0.05 cFWE) versus controls.

• Why it matters: It is unclear whether functional brain activation differences are shared across different psychiatric disorder risks, despite varied phenotypic versus familial designs and task types.
• What they did: A meta-analysis of 101 task-based fMRI studies (2534 high-risk participants, 2686 controls) pooled peak voxel coordinates and used random-effects activation likelihood estimation in JALE, with permutation-based cluster-level cFWE correction.
• The result: About 30% of studies within each risk group contributed to the left lateral prefrontal cortex convergence, and psychosis risk additionally showed alterations in the orbitofrontal cortex and anterior insula.

AI summary of the abstract · may contain errors · not medical advice · read the paper.