The Efficacy of Cefazolin and Ertapenem combination treatment for Persistent MSSA Bacteraemia: A ten-year multicentre retrospective cohort study.

Cefazolin–ertapenem combination therapy in adults with persistent Staphylococcus aureus (MSSA) bacteraemia is linked to faster blood culture sterilisation, with a median 1-day time to clearance.

• Why it matters: Persistent MSSA bacteraemia carries substantial morbidity and mortality, and clinical comparative evidence for this combination has been limited despite preclinical synergy.
• What they did: In a 10-year multicentre retrospective cohort of adults (>18 years) from two Queensland tertiary hospitals (Jan 2014–Dec 2024), time to blood culture sterilisation was compared between 14 early-combination patients and a matched non-combination cohort (n=114).
• The result: Combination therapy increased the rate of blood culture clearance (HR 1.8; 95% CI 1.2–2.7; P=0.004), while 90-day mortality (20.0% vs 23.0%; P=0.73) and relapse (11.5% vs 8.3%; P=0.57) were not significantly different.

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