Epidemiology of acute respiratory infections in adult patients in Hospices Civils de Lyon, France, between October 2016 and April 2025

In a retrospective cohort of 82,077 adults with 103,011 Hospices Civils de Lyon ARI visits (Oct 2016–Apr 2025), patients aged ≥65 had longer stays and higher in-hospital mortality.

• Why it matters: Viral circulation and severity patterns for acute respiratory infections are needed to guide surveillance and identify which adult groups are most at risk of deterioration and resource use.
• What they did: Electronic health records were used to extract administrative variables and laboratory-confirmed viral detections from eligible hospitalizations or emergency presentations, including ICD-10 ARI codes.
• The result: Compared with younger adults, those aged ≥65 had median hospitalisations of 10 vs 8 days (p<0.001), twice the in-hospital mortality (14% vs 7%, p<0.001), fewer ICU admissions (21% vs 33%, p<0.001), and less respiratory support use.

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