Cortical Thinning in Adults with Prader-Willi Syndrome: Distribution Across Functional Networks and Associations with BMI and the GH/IGF-1 Axis

Adults with Prader-Willi syndrome show reduced cortical thickness in a left-hemispheric cluster spanning inferior precentral gyrus, insula, inferior temporal cortex, and orbitofrontal cortex.

• Why it matters: Prior work in adults with Prader-Willi syndrome has highlighted regional gray matter differences, but the large-scale functional network distribution of cortical thickness changes is unclear.
• What they did: Structural MRI was analyzed in 23 adults with Prader-Willi syndrome and 22 age- and sex-matched controls using FreeSurfer, with group differences tested via covariates and Spearman correlations for clinical, cognitive, anthropometric, and endocrine measures.
• The result: Lower cortical thickness in the Prader-Willi syndrome group is linked to higher body mass index and poorer global functioning, and it is positively associated with IGF-1 levels and greater in those with childhood growth hormone therapy history.

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