Monoaminergic changes are associated with impaired neurogenesis along the longitudinal axis of the hippocampus in ageing and dementia

In post-mortem hippocampus tissue from Parkinson disease dementia cases, DCX and MKI67 expression are markedly reduced across the longitudinal axis, linked to altered DOPAC and 5-HIAA levels.

• Why it matters: Adult hippocampal neurogenesis is reduced in normal ageing and Parkinson disease dementia, but the monoaminergic mechanisms and how deficits vary along the hippocampal axis are unclear.
• What they did: The study quantified gene expression for neurogenesis stages and measured monoaminergic activity throughout the hippocampus in young, aged, and PDD individuals, then used hierarchical regression to test predictors of DCX and MKI67.
• The result: DOPAC and 5-HIAA independently predict DCX and MKI67 expression regardless of diagnostic group, and stem-cell-to-proliferation coupling is preserved in young controls but absent in aged controls and PDD.

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