Proteome-Wide Serology Identifies Secreted IgD against RSV Fusion Glycoprotein as a Signature of Broadly Elevated Antibody Response

Secreted IgD against RSV fusion glycoprotein F is detected in 52% of 214 healthy maternal serum samples, with anti-RSVF IgD levels linked to broadly elevated antibody responses.

• Why it matters: Conventional immunoassays miss the breadth and functional complexity of polyclonal antibodies, limiting serology-based insight into diverse immune responses to RSV.
• What they did: The ProWiSe mass spectrometry platform performed proteome-wide, absolute quantification of antigen-specific human antibodies across isotypes, subclasses, and IGHV repertoires in maternal serum.
• The result: Anti-RSVF IgD (≥0.11 ng/mL) correlated with elevated levels across nearly all other isotypes and subclasses, except IgE, enabling quantitative diagnostics and discovery of rare antibody isotypes.

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