Enhancers Silence Coupled-coding RNAs in Animals

Regulatory non-coding genes in animals are independent transcription units marked by arginine methylation of nucleosomes in their gene bodies, regulated by JMJD5.

• Why it matters: The field lacks a clear mechanism and biogenesis model for regulatory non-coding RNAs, and how animals’ transcriptional regulation differs from simpler unicellular organisms.
• What they did: The study maps regulatory non-coding genes as separate transcription units and shows enhancer RNAs target the 3-prime UTRs of coupled coding RNAs, with shared transcription factors and promoter-proximal RNA Polymerase II pausing.
• The result: Temporal and spatial coding genes are intrinsically coupled with regulatory non-coding genes in animals, suggesting a coordinated regulatory program for animal development.

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