PIM6 Induces Tolerance and Confers Protection against Mycobacterium tuberculosis in Primary Macrophages

PIM6 pretreatment of primary human monocyte-derived macrophages tolerizes innate responses and enables early improved control of Mycobacterium tuberculosis H37Rv.

• Why it matters: Glycolipids in the mycobacterial envelope can reshape host innate signaling, but how PIM6 affects monocyte/macrophage responsiveness and subsequent bacterial control is unclear.
• What they did: Primary human monocytes and MDMs were prestimulated with PIM6, rested for 5 days, then challenged with LPS or infected with H37Rv Mycobacterium tuberculosis; cytokines and pattern recognition receptor expression were measured.
• The result: After LPS challenge, PIM6-pretreated cells secreted attenuated TNF-, IL-6, and IL-10, and infection showed decreased TNF- and IL-10 with early increased bacterial control.

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