The YjfJ protein is the effector of a second PspA/VIPP1 system that is widespread in the Gammaproteobacteria

YjfJ-like proteins form a second, phylogenetically distinct PspA/VIPP1 subtype in Gammaproteobacteria, occurring at similar frequencies to PspA-like proteins.

• Why it matters: The canonical PspA system has been studied mainly in Escherichia coli and Yersinia enterocolitica, leaving non-canonical PspA/VIPP1 variants insufficiently characterized across genomes.
• What they did: The authors surveyed PspA/VIPP1 content across a diverse set of Gammaproteobacterial genomes to identify two subtypes and compare their associated accessory proteins.
• The result: YjfJ-like systems have unique accessory sets and, in some species such as Pseudomonas aeruginosa, are the only PspA/VIPP1 system, supporting equal conservation and distribution.

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