Divergent Causes of Death After Ischemic and Hemorrhagic Stroke in the Reperfusion Era: A Contemporary Cohort Study

In a contemporary cohort of 1,344 ischemic and hemorrhagic stroke survivors, post-discharge deaths over 5.2 years shift from cerebrovascular causes to cardiac disease after ischemic stroke (31.6%).

• Why it matters: Modern reperfusion-era data on long-term, cause-specific mortality after stroke are limited, especially compared with in-hospital decedents and by stroke subtype.
• What they did: Adults hospitalized for ischemic or hemorrhagic stroke at Cedars-Sinai (OSCAR) from 2017–2020 were identified via billing-code/imaging plus large language model-assisted chart review, then followed through June 30, 2025.
• The result: Among discharged ischemic stroke survivors, cardiac disease is the leading cause of death (31.6%), including sudden cardiac arrest (10.9%), while hemorrhagic survivors show cancer as leading (38.9%).

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