A Multilevel Framework for Evaluating the Impact of Monoclonal Antibodies Against Respiratory Syncytial Virus in Daycare and Households

Infant immunization with monoclonal antibodies against RSV is expected to yield only modest indirect protection for toddlers in a U.S.-informed virtual population.

• Why it matters: Indirect protection for unimmunized contacts is unclear because population-level RSV transmission effects of infant mAbs are not well characterized.
• What they did: The study built a multiscale simulation linking RSV spread across households and daycare centers, using a virtual U.S. population with age heterogeneity, time-varying infectiousness, and realistic contact patterns.
• The result: The strength of indirect effects depends on contact structure and intervention coverage, supporting network-based evaluation of RSV prevention strategies.

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