Feasibility and Acceptability of a Prospective Remote Pilot Study for Assessment of Airborne Environmental Exposures and Male Fertility

In a prospective pilot cohort of 18 healthy men aged 21–44 years, 16 (89%) completed subsequent remote semen and blood sampling, with at-home semen collection preferred.

• Why it matters: Serial sampling and exposure monitoring are needed to study links between airborne environmental exposures and male reproductive health, but remote feasibility and acceptability are unclear.
• What they did: Participants used PurpleAir monitors for indoor/personal environmental exposure and Fresh Air wristbands, while collecting homeRNA capillary blood and Fellow Semen Analysis Kit semen samples.
• The result: Both remote and in-clinic methods were rated easy with minimal blood discomfort; all 16 completing the final survey would join again and were willing to provide a median of 18 semen and 18 blood samples.

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