Biomarkers of ageing and lung function trajectory: a multi-omics study in a UK birth cohort

Higher childhood plasma CXCL10, IL6, and IL33 are linked to membership in the Persistently Low FEV1 trajectory (ages 8–30) in the UK ALSPAC cohort.

• Why it matters: Early-life lung function trajectories may help prevent COPD, but it is unclear whether epigenetic or senescence-related ageing biomarkers track with these adverse patterns.
• What they did: Using logistic regression, the study tested nine blood epigenetic age acceleration measures and thirteen senescence-associated plasma proteins measured at ages 7–9 against two lowest FEV1 trajectory groups. Bidirectional one-sample Mendelian randomisation assessed causation.
• The result: EAA showed little evidence of association with lower trajectories, while CXCL10 (OR 1.29 per SD), IL6 (OR 1.29), and IL33 (OR 1.23) were associated with Persistently Low membership; genetically proxied childhood FEV1 predicted higher CXCL10 at ages 9 (beta -0.34) and 24 (beta -0.38).

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