MULTI-COHORT TRANSCRIPTOMIC ANALYSIS REVEALS SHARED INFLAMMATORY SIGNALING AND UROTHELIAL DYSFUNCTION ACROSS IC/BPS PHENOTYPES

Across four human IC/BPS transcriptomic cohorts, bladder-tissue disease is linked to reduced urothelial differentiation/barrier markers and increased TLR4 recognition and pro-inflammatory signaling, consistently.

• Why it matters: IC/BPS is clinically heterogeneous, but the shared molecular programs spanning non-ulcer/non-Hunner, ulcerative/Hunner, and capacity-based phenotypes are not well defined.
• What they did: The study reanalyzed four independent datasets using immune-cell-associated expression, urothelial differentiation/barrier integrity, TLR4/pro-inflammatory signaling, and AOAH expression across bladder tissue and urine sediment phenotypes.
• The result: AOAH expression was elevated in all three bladder-tissue cohorts and associated with monocyte/macrophage and pro-inflammatory transcriptional states, while severe ulcerative and low-capacity phenotypes showed concordant leukocyte/monocyte/macrophage, enhanced TLR4 signaling, elevated AOAH, and reduced urothelial barrier-associated expression.

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