Deterministic DNA-first discovery reveals recurrent genomic architectures

DNA-first genomic architecture discovery localized seven of eight predeclared array-associated ART loci, including all seven with exact-array coordinates, using asymmetric-covariance natural-vector representations plus positional recurrence.

• Why it matters: Genome mining often starts from known genes or protein families, which can miss systems defined mainly by genomic organization. This work targets that gap by using raw DNA features to nominate architectures for RNA-to-DNA studies.
• What they did: In benchmarks of array-associated reverse transcriptase (ART) loci, the framework joined separately calibrated signals via genomic coordinates and used a DNA-first localization step. It also ran a profile-guided search across 6.12 Gb and evaluated an independent 54.38-Gb dataset.
• The result: Dual-arm signals were absent in all three non-array RT controls and present in one of five UG27 systems, indicating selectivity in small control sets. In the 54.38-Gb evaluation, structural compatibility was 24/32 under a historical-rule mirror, 12/32 after novelty-only selection, and 0/17 for architecture-selected complete ORFs, with six exact sequences shared across the two 32-member panels.

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