Lipidome of Compact Myelin from Cortical Regions of the Aging Murine Brain

Compact myelin isolated from cortical regions of aging Mus musculus shows age-linked lipidome remodeling, with 414 lipid species changing across young adult, middle-aged, and aged cohorts.

• Why it matters: Age-related cognitive decline is linked to neurodegeneration in cortical white matter, but the biochemical lipid changes that precede myelin structural loss are not well defined.
• What they did: Compact myelin was enriched from cortical regions using refined density centrifugation and profiled by LC-MS/MS across young adult, middle-aged, and aged mice, identifying over 2000 lipid species.
• The result: Aging is associated with overall decreases in high-abundance glycerophospholipids and sphingolipids (including phosphocholine, phosphoethanolamine, sphingomyelin, and cerebrosides), with pathway analyses implicating altered lipid metabolism and membrane bilayer stability.

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