GOParsimony: parsimonious saltation across the Gene Ontology digraph for efficient functional annotation

GOParsimony saltates across the Gene Ontology digraph to assign term precedence, yielding a most parsimonious GO set where precedence equals 1.

• Why it matters: GO term lists are often redundant and overly large, and existing filtering approaches rely on predefined term sets or arbitrary semantic-distance thresholds.
• What they did: The tool updates cascades of GO term precedence until convergence, then outputs precedence graphs and heatmaps for five example budding yeast and human datasets.
• The result: In default mode, it consistently reduces GO term lists while increasing significance and maintaining low or intermediate coverage of the space of significant GO terms versus other distributed methods.

AI summary of the abstract · may contain errors · not medical advice · read the paper.