An RNA-centric atlas of human cell cycle regulation

Palbociclib-synchronised normal diploid human cells show 104 cell cycle-regulated lncRNAs, including ENSG00000230615, whose perturbation alters cell cycle progression and downregulates neighbouring KLF17.

• Why it matters: Protein networks coordinate division, but RNA-mediated control of the human cell cycle is less mapped, limiting understanding of how RNA features tune timing and transitions.
• What they did: The study profiled lncRNAs, transposable elements, alternative splicing, and RNA-binding proteins across the cell cycle in palbociclib-synchronised normal diploid cells, identifying 104 regulated lncRNAs and validating ENSG00000230615.
• The result: It found 297 TE loci with cell-cycle differential dynamics (with Alu upregulated at the G1-to-S transition) and 598 genes with cell-cycle-dependent AS, plus cytokinesis proteins acting as non-canonical RBPs with RNA-dependent stability.

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