Intra-individual changes to peak alpha frequency map to pain perception following high frequency sensitisation of central nociceptive pathways: A test-retest reliability study

Inter-individual changes in global PAF after 128 mN MPS show good test-retest reliability across two identical sessions, but no specific regional EEG driver emerges.

• Why it matters: Global oscillation slowing is seen in sensitised pain states, yet it is unclear whether peak alpha frequency and alpha-band power have mechanistic specificity for pain perception.
• What they did: Resting-state EEG was recorded in two test-retest sessions while high-frequency stimulation induced SHA, quantified by 128 mN MPS; blind source separation assessed sensorimotor components and their reliability.
• The result: Alpha-band power influenced MPS at baseline and post-HFS, but its test-retest reliability was poor and component localization to pre-/post-central gyri was limited, implying cautious use for tracking.

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