Circadian Clock Coordination of the Notch-to-Wnt Signaling Switch Promotes Regenerative Myogenesis

Circadian clock activity coordinates the Notch-to-Wnt signaling transition in regenerating muscle, promoting MuSC proliferative expansion and myogenic progression, including in dystrophic models.

• Why it matters: Regenerative failure in muscular dystrophy is linked to deficits in MuSCs, and the mechanisms controlling the Notch-to-Wnt switch needed for repair remain unclear.
• What they did: Using complementary genetic and pharmacological approaches, the study mapped clock activity in cycling myogenic progenitors, tested clock induction alongside Notch activation, and identified Notch pathway components as direct transcriptional targets.
• The result: Clock coordination of Notch and Wnt is linked to enhanced MuSC expansion and myogenic progression during regeneration, preserved in dystrophin-deficient mouse and human myoblasts, and improved by clock-activating compounds in dystrophic muscle.

AI summary of the abstract · may contain errors · not medical advice · read the paper.