Resonant Recognition Model analysis of cGAS: conserved spectral frequencies and a divergent naked mole-rat phase signature

RRM analysis of mammalian cGAS sequences identifies a dominant conserved spectral frequency (f = 0.2539) whose amplitude tracks body mass and lifespan-to-body-mass ratio.

• Why it matters: Functional divergence of cGAS between humans and naked mole-rat may or may not appear in primary-sequence-derived spectral signatures, and the stakes are linking sequence features to interaction modes.
• What they did: cGAS sequences from fourteen mammals and FANCI sequences from eight species were converted using EIIP values, analyzed by discrete Fourier transform, and compared via consensus spectra and phase differences at RRM frequencies.
• The result: cGAS amplitude at f = 0.2539 correlated with body mass (r = 0.647, p < 0.05) and lifespan-to-body-mass ratio (r = -0.677, p < 0.01), with naked mole-rat showing the lowest amplitude; phase criteria supported human cGAS-FANCI (3.1297 rad) but not naked mole-rat (1.7319 rad), and the dominant frequency maps to a predicted 792 nm wavelength (378.5 THz).

AI summary of the abstract · may contain errors · not medical advice · read the paper.