Next generation Human Neocortical Neurosolver model with biophysically realistic somatic, dendritic and synaptic dynamics

An updated Human Neocortical Neurosolver model tunes electrophysiology and synaptic connections to human tissue, reproducing realistic somatic dynamics and dendritic Ca2+ spikes in L5 ET pyramidal neurons.

• Why it matters: Human EEG/MEG interpretation needs multiscale models grounded in human recordings, but earlier HNN circuitry relied on rodent and non-human primate data when human neuronal dynamics were less known.
• What they did: The authors updated HNN with human-tuned electrophysiological properties and synaptic connectivity, adding L5 extratelencephalic-projecting dendritic Ca2+ spikes and shorter L2/3 dendritic spikes, then used the software to separate somatic, synaptic, and dendritic contributions to E-/MEG signatures.
• The result: The enhanced HNN distribution includes workflows for event-related responses and oscillations plus tutorials for membrane potentials, Ca2+ dynamics, and synaptic currents, enabling extensive validation against in vitro and in vivo electrophysiology and imaging.

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