RCDome: A Multi-Database Human Gene Atlas of Regulated Cell Death

RCDome compiles 22,473 human gene–regulated cell death associations across 9,265 HGNC-validated genes, grounding evidence for 23.8% mechanistic pairs and exposing 1.3% database-only links.

• Why it matters: Gene–RCD links often disagree across databases and many lack traceable primary-literature support, making it hard to determine where an association came from and how reliable it is.
• What they did: The team integrated evidence from 20 public databases using five channels (PubMed Boolean search, curated resources, AI-assisted screening, manual curation, and Elicit review), then validated and recovered sources via DeepSeek, Europe PMC full-text extraction, consensus searching, and GPT-4o arbitration.
• The result: Evidence-first adjudication resolved 5,138 pairs as mechanistically involved, with 225 executors and 4,455 regulators among role-resolved pairs, and only 286 rows lacked any verifiable paper trail.

AI summary of the abstract · may contain errors · not medical advice · read the paper.