Two closely related RNA helicases, UAP56 and URH49, couple mRNA splicing and export pathways with their distinct complexes

UAP56 and URH49, two related RNA helicases, regulate splicing before export and generate three splicing–export patterns linked to cooperative versus selective mRNA export.

• Why it matters: Integration of transcription with mRNA processing requires splicing to be coordinated with export, but how these helicases and their distinct complexes shape pathway choice was unclear.
• What they did: The study analyzed splicing and export outcomes for UAP56 and URH49, identifying Type I–III splicing regulation patterns and testing how apo- vs ATP-state complex formation affected those patterns.
• The result: Type I splicing control aligned with cooperative export, while Type II and Type III were associated with selective export, implying complex-specific remodeling tunes transcriptome regulation beyond export.

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