Rapid Progesterone signaling induces meiosis through a dual coreceptor trafficking trap

In the frog oocyte, progesterone triggers meiotic arrest release via a PM trafficking trap that increases mPRβ–ABHD2 affinity and traps ABHD2 at the membrane.

• Why it matters: Rapid progesterone signaling is known to act within seconds to minutes, but the early molecular steps that enable meiotic progression in oocytes were unclear.
• What they did: The study mapped early signaling by analyzing how progesterone binding alters mPRβ (PM-localized) and ABHD2 (intracellular) interactions, including ABHD2’s role as a dual-pass transmembrane protein that activates intracellular PLA2.
• The result: Progesterone is essential under physiological conditions for the mPRβ–ABHD2 interaction and PM trapping, enabling signaling that induces meiosis through a novel coreceptor trafficking mechanism.

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