Proteomic clocks reveal organ-specific signatures of aging in mice

Organ-specific proteomic aging clocks in eight mouse organs show age-linked protein signatures that replicate across cohorts but transfer poorly between organs within the same mice.

• Why it matters: It remains unclear whether proteomic aging patterns are shared across organs and how they align with RNA, especially since plasma proteomics cannot measure organ protein abundance directly.
• What they did: The study built organ-specific proteomic clocks from eight mouse organs, tested cross-cohort retention and within-mouse cross-organ transfer, then applied protein-derived feature weights to transcriptomes and spatial transcriptomes.
• The result: Protein-derived RNA scores retained age associations with stronger effects in matching organs, and in paired analyses protein tracked age more strongly than RNA in brain and skeletal muscle, while spatial niches showed rising protein-derived RNA scores with age without niche shifts.

AI summary of the abstract · may contain errors · not medical advice · read the paper.