Effect of food-cues on aMCC glutamate modulation during inhibitory control post weight loss intervention: a 1H fMRS study

Lower aMCC glutamate modulation during food/non-food cues was observed during selective response inhibition in 27 adults with overweight/obesity.

• Why it matters: Poor inhibitory control may undermine weight loss maintenance, but the neurobiological role of glutamate during cue-driven inhibition is not well characterized.
• What they did: Participants completed a visual response inhibition task with selective (withholding on 20% of trials) versus non-selective responding under neutral (squares) versus food/non-food cues, while 1H fMRS measured midline aMCC glutamate modulation.
• The result: In the selective condition, glutamate modulation was linked to long-term weight change as a close trend (R2=0.15, p=0.054) and was significantly associated with TFEQ Cognitive Restraint (R2=0.20, p=0.047).

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