The prevalence of type 2 diabetes mellitus among people with amyotrophic lateral sclerosis is increasing in the United States

Among people with amyotrophic lateral sclerosis (ALS) in US EHRs, comorbid type 2 diabetes mellitus (T2DM) prevalence rose from 5.2% in 2011 to 12.1% in 2021.

• Why it matters: T2DM has been linked to different ALS risk patterns, yet comorbidity prevalence in ALS populations and its decade-long trajectory in the US remained unclear.
• What they did: Using multi-center EHR data in GROUSE (2011–2021) and validated algorithms to identify ALS and T2DM, the authors calculated annual prevalence and tested 2011–2021 trends with mixed linear models adjusted for age and sex.
• The result: T2DM prevalence increased by 132.7% among people with ALS, outpacing the 29% relative increase in the overall population from 2011 to 2021.

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