Association of dietary protein intake with accelerated biological aging markers and all-cause mortality in adults

Higher dietary protein intake (g/kg/day) is linked to lower odds of accelerated biological aging in NHANES adults, with the strongest reported effect for TL (OR: 0.40, 95% CI: 0.22–0.73).

• Why it matters: The study addresses uncertainty about whether dietary protein intake is associated with biological aging markers and whether those markers help explain links to all-cause mortality.
• What they did: Using NHANES cycles 1999–2000 and 2001–2002, protein intake was modeled in g/kg/day and biological aging was estimated with TL, AnthropoAge, PhenoAge, and KDM; accelerated aging was defined using TL thresholds.
• The result: Compared with the lowest quintile (<=0.62 g/kg/day), higher intake (>=1.40 g/kg/day) showed lower odds for accelerated aging by TL, PhenoAge, and KDM, and BA markers partially mediated associations with lower all-cause mortality.

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