Post-psychedelic and meditation-related challenges: a protocol for a mixed-methods longitudinal-observational study

Enriched-sample observational study will characterize persisting psychedelic- and meditation-related challenges using WHODAS 2.0 and symptom/phenomenology measures across N=1,600 retrospective and n=800 prospective participants.

• Why it matters: Adverse effects after psychedelic use and meditation practice are poorly characterized, especially their clinical features, longitudinal course, and diversity, limiting comparison between these overlapping experiences.
• What they did: The protocol uses an active-comparator design with two parallel arms of 800 each, combining a cross-sectional retrospective survey (N=1,600), 12-month follow-up with six bimonthly surveys (n=800), 12 weeks of weekly ambulatory assessments (n=40), and qualitative interviews (n=60).
• The result: It will map phenomenology, course, and functional impact, validate a tailored item pool’s structure and psychometrics, and release a publicly available de-identified dataset for syndrome matching and cross-arm trajectory and measurement comparisons.

AI summary of the abstract · may contain errors · not medical advice · read the paper.