Scalable hardware and software for high-density, multi-regional electrophysiology in non-human primates

The Multi-regional Implantable NeuroDrive (MIND) enables stable, chronic multi-probe Neuropixels recordings across parietal, prefrontal, and motor cortices in rhesus macaques.

• Why it matters: Long-duration, multi-region recordings are needed to link distributed neural circuits to complex, naturalistic behaviors, but NHPs require compact implantable hardware and reliable automated spike sorting.
• What they did: The authors co-designed MIND, a lightweight implantable microdrive for chronic ambulatory head-free recordings, and UnitAssay, an automated post-sorting curation framework that targets spike-sorting errors with minimal computational cost.
• The result: In rhesus macaques performing reaching and eye-movement tasks, MIND supported stable multi-probe recordings, and UnitAssay improved reliable single-unit identification relative to Kilosort 4 labels and standard SpikeInterface quality control.