phyB photobodies display molecular memory, regulating light signaling transcriptional states through phase separation.

Arabidopsis thaliana phyB photobodies show cell-type specific molecular memory, with stability differences linked to light quality and red-light–dependent transcriptional states.

• Why it matters: Condensates are proposed to store molecular history, but the biological relevance of phyB photobody formation for light signaling memory and transcriptional regulation remained unclear.
• What they did: Using live imaging plus FRAP, the authors measured photobody size/intensity constraints and mobility differences across cell types under light perturbations, then validated with whole-mount confocal imaging and single-nucleus transcriptomics.
• The result: Sci-Seq spatial transcriptomics identified a photobody-associated nuclear cluster regulating photosynthesis, circadian rhythm, and RNA processing, with phyB likely promoting its own stability via TZP expression.

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