Reversible chromatin remodeling enables Prosopis cineraria survival under recurrent heat extremes.

Seasonal chromatin remodeling in Prosopis cineraria weakens heat-time chromatin boundaries and merges topological domains, activating heat-protective gene clusters enriched for H3K4me3 and H3K27ac.

• Why it matters: Warming increases recurrent heat and drought, but how long-lived desert trees keep physiological function across repeated seasonal extremes remains unclear.
• What they did: Using seasonal Hi-C, transcriptomics, histone-mark, and DNA-methylation profiling at six time points, the study mapped heat-peak chromatin changes and linked them to an SA–ABA reciprocal seasonal profile and MIZ1-associated hydrotropism.
• The result: Chromatin activation aligns with Stay-Green-mediated delayed senescence via chlorophyll retention and suggests a proactive developmental phase near transposable elements, while landscape genomics and phylogenetics implicate a housekeeping PEPC with high predicted melting temperature for heat-buffered metabolism.

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