medRxivJClub
Micro-fragmented adipose tissue reprogrammes the systemic molecular landscape of inflammatory knee osteoarthritis
medRxiv · · Preprint · Open access
Primorac, Molnar + 8 more
Abstract ↗AI summary
The abstract is read at the publisher; the summary is JClub's.
In a double-blind randomized trial in knee osteoarthritis, intra-articular micro-fragmented adipose tissue (MFAT) produced distinct systemic molecular fingerprints by six months, unlike hyaluronic acid (HA).
- Why it matters: Pain and function improvements alone cannot determine whether knee osteoarthritis disease biology changes or symptoms only shift.
- What they did: The study integrated longitudinal plasma proteomics, N-glycomics, and miRNA transcriptomics with baseline genetics and prior networks using interpretable AI data fusion (non-negative matrix tri-factorisation), resolving 93 gene and 30 miRNA pathways at baseline, one, and six months.
- The result: By six months, HA remained linked to canonical OA and synovial inflammation markers, including MMP13 and LIMK2, while MFAT shifted blood pathways toward chondroprotection and anti-inflammatory signalling, prioritizing SIRT7 and NDUFC1.
The findingWhy it mattersWhat they didThe result
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