Neuroimaging Summary Scores Predict Trajectories of Psychotic-Like Experiences in Youth

Adolescents in the Persistent Elevated distressing PLE trajectory (N=1,968; 21%) show higher Multimodal and T1-weighted Psychosis Neuroscores than all other trajectories (ORs 1.27–1.34, pFDR<.01).

• Why it matters: Persistent distressing PLEs in youth are linked to neurobiological differences and later psychosis risk, but early stratification using individual neuroimaging liability is still limited.
• What they did: In the Adolescent Brain Cognitive Development Study (N=9,584; ages 9–10 at baseline), latent growth mixture models used four annual PLE assessments, while baseline T1-weighted and diffusion imaging informed Psychosis Neuroscores.
• The result: Psychosis Neuroscores distinguished Persistent Elevated from other trajectory groups and showed comparable links to established risk factors, though modifiable factors (screen time, physical activity, sleep disturbances) had smaller or stronger associations.

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