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Scanning DIA on the ZenoTOF 8600 system records a precursor dimension for every fragment at tenfold higher ion flux
bioRxiv · · Preprint · Open access
Heymann, Oliinyk + 26 more
Abstract ↗AI summary
The abstract is read at the publisher; the summary is JClub's.
ZenoTOF 8600 MS2 ion current increases tenfold over the ZenoTOF 7600+ while ZT Scan DIA records each fragment’s precursor Q1 profile for wide-window sensitivity.
- Why it matters: Proteomics needs DIA methods that preserve quantitative precision and depth despite wide isolation windows that normally reduce selectivity.
- What they did: The authors implement ZT Scan DIA on the quadrupole time-of-flight ZenoTOF 8600, where scanning quadrupole DIA links every fragment to its precursor Q1 profile.
- The result: ZT Scan DIA identifies up to 38% more precursors than variable-window DIA, improves quantitative accuracy, and quantifies up to 10,000 protein groups per run.
The findingWhy it mattersWhat they didThe result
- Open access
- 2 cites