Genomic identification and multi-tissue transcriptomic profiling of vitamin D3-related genes in Atlantic salmon (Salmo salar)

Atlantic salmon (Salmo salar) has 16 vitamin D3-related genes, including 14 pathway orthologs and two albumins, with expression patterns across a 14-tissue atlas and seven RNA-seq studies.

• Why it matters: Mammalian vitamin D3 pathways are well mapped, but teleost genetic components and tissue usage are unclear, limiting interpretation of vitamin D3 metabolism and dietary requirements in fish.
• What they did: The team identified 16 genes, resolved seven paralog pairs from the salmonid whole-genome duplication, and profiled expression in a 14-tissue atlas plus seven independent RNA-seq datasets.
• The result: Kidney activation via renal cyp27b1 appears weak or absent across sampled conditions, while cyp27b1.a and cyp27b1.b show brain and liver expression, supporting hypotheses that activation may not rely on renal cyp27b1 and that albumins/lipoproteins may carry metabolites.

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