bioRxivJClub
Co-evolutionary dynamics of defense systems and anti-defense genes in chromosomes and mobile genetic elements of Enterobacteriaceae
bioRxiv · · Preprint · Open access
Liu, Ahator + 2 more
Abstract ↗AI summary
The abstract is read at the publisher; the summary is JClub's.
In 6,907 Enterobacteriaceae genomes, defense (DEF) gene turnover is highest on chromosomes, intermediate on plasmids and ICEs/IMEs, and lowest on prophages.
- Why it matters: Genomic compartment effects on how defense and anti-defense genes evolve are unclear, limiting understanding of how bacterial immune-like systems and countermeasures diversify.
- What they did: Using a phylogenetic birth-death model, the study quantified gain, loss, expansion, and reduction of DEF and anti-DEF gene families across chromosomes and mobile genetic elements.
- The result: MGE-associated anti-DEFs show higher loss, expansion, and reduction than DEFs, while chromosome-associated anti-DEFs show lower gain; DEF and anti-DEF gains/losses are positively correlated across lineages.
The findingWhy it mattersWhat they didThe result
- Open access