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Administration of short-chain fatty acids reduces bacterial translocation to peripheral organs and the brain, preserves gut barrier integrity, and mitigates brain injury following stroke.
bioRxiv · · Preprint · Open access
Castillo Gonzalez, Mousavi + 8 more
Abstract ↗AI summary
The abstract is read at the publisher; the summary is JClub's.
In a mouse middle cerebral artery occlusion model, stroke-linked bacterial translocation to liver, lungs, spleen, and brain persists in the CNS despite systemic resolution by 7 days.
- Why it matters: Post-stroke infections are a major cause of death, but the timing and spread of bacterial translocation—and whether it worsens outcomes—remain insufficiently defined for therapy development.
- What they did: The study tracked spatiotemporal bacterial dissemination after stroke, finding initiation at 6 hours, peak between 24 hours and 4 days, and near-complete systemic resolution by 7 days; SCFA treatment was then tested.
- The result: SCFAs reduced systemic and cerebral translocation, preserved gut barrier integrity, reversed post-stroke immunosuppression, reduced infarct volume and blood-brain barrier leakage, and improved survival.
The findingWhy it mattersWhat they didThe result
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- Open access
- 2 cites