bioRxivJClub
Insular opioid signaling and distinct claustral ensembles in hedonic feeding
bioRxiv · · Preprint · Open access
Chen, Mangieri + 12 more
Abstract ↗AI summary
The abstract is read at the publisher; the summary is JClub's.
A single forced swim increases palatable-food intake in mice, and deleting or blocking claustral kappa-opioid receptors (KORs) attenuates this stress-linked hedonic feeding.
- Why it matters: Stress can promote palatable eating without energy need, but the specific stress-signal pathway and claustral circuit mechanisms controlling hedonic feeding were unclear.
- What they did: In mice, the authors used claustral KOR deletion/blocking and a KOR-based sensor to track opioid tone, then mapped anterior insular cortex (aIC) prodynorphin (Pdyn) projections to claustrum and imaged distinct claustral neuron subsets during eating.
- The result: Eating reduces claustral opioid tone at onset, recruits vGAT neurons broadly, and splits KOR-Cre neurons into activated and suppressed groups; Pdyn loss in aIC increases palatable intake and KOR ligands alter engagement with palatable food.
The findingWhy it mattersWhat they didThe result
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- Open access
- 4 cites