Monovalent degraders can recruit two E3 ligases simultaneously to degrade SMARCA2/4, with tunable dependency on DCAF16 or FBXO22.
- Open access
- 2 cites
Click Chemistry and Applications
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CLEO4-88 acts as a molecular glue with an EC50 of 12.5 nM to inhibit ACAA1 thiolase by inducing binding to GID4 in vitro and in cells.
- 1 cites
Artificial metalloenzymes can be engineered to function effectively in complex biological environments, including cell lysates, surfaces, and intracellular spaces, overcoming previous limitations.
PRADA enables in vivo proximity labeling of proteins and RNAs across multiple organisms, revealing RNA folding as a key regulator of mitochondrial gene expression.
Bitopic kinase inhibitors designed with optimized parameters can surpass existing drugs like ponatinib in potency and safety, especially against resistant ABL1 mutants.
- Open access
Heterobifunctional protein binders achieve cell-type-specific targeting with subnanomolar potency via FKBP12-dependent enrichment.
- Open access
Lantern achieves sub-minute, spatially precise RNA and protein labeling in eukaryotic cells, enabling detailed mapping of subcellular molecular networks.
- Open access
- 1 cites
Modular in vivo antibody-ADC click strategy enhances tumor targeting and overcomes resistance in heterogeneous cancers, showing improved activity in preclinical models.
- Open access
High-throughput chemical modification of ligands yields 3,163 compounds, leading to the discovery of novel chemical inducers of proximity with therapeutic potential.
- Open access
- 5 cites
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