Nature Chemical Biology · 1 Sept 2026 · Journal Article

Proteins feel the PINCH.

Kodadek

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The molecular glue CLEO4-88 inhibits the ACAA1 thiolase by induced binding to GID4.
Nature Chemical Biology · 1 Oct 2026 · Journal Article
CLEO4-88 acts as a molecular glue with an EC50 of 12.5 nM to inhibit ACAA1 thiolase by inducing binding to GID4 in vitro and in cells.
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A prodrug glue.
Nature Chemical Biology · 1 Oct 2026 · Journal Article
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Dual E3 ligase recruitment by monovalent degraders for tunable SMARCA 2/4 degradation.
Nature Chemical Biology · 1 Oct 2026 · Journal Article
Monovalent degraders can recruit two E3 ligases simultaneously to degrade SMARCA2/4, with tunable dependency on DCAF16 or FBXO22.
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