Blinatumomab consolidation reduces relapse and improves survival in high-risk Ph- B-ALL patients, with 5-year relapse at 23% versus 49% in controls.
- 7 cites
Acute Lymphoblastic Leukemia research
Moving in Blood.
- Moved this week
- 1
Rebuilt
Moved this week
Latest in Acute Lymphoblastic Leukemia research
Newest first · last 60 days
Venetoclax combined with pediatric-inspired chemotherapy achieves a 91% remission rate and improves survival in adolescents and adults with newly diagnosed Ph-negative ALL.
- Open access
- 1 cites
Ablating endothelial PERK enhances DLL4-NOTCH3 signaling, boosting lymphoid regeneration by 50% after irradiation in hematopoietic recovery.
- Open access
Inhibiting WNK1, an atypical kinase overexpressed in T-ALL, induces cell cycle arrest and disrupts mitosis, offering a promising therapeutic target with significant effects.
- Open access
Genomic and epigenomic profiling reveal over 40 molecular subtypes of acute lymphoblastic leukemia, enhancing classification and informing treatment strategies.
Combining genetics and MRD assessment identifies adult Ph- ALL patients who benefit from allo-HSCT, with a 3-year OS of up to 81% in low-risk groups.
- 1 cites
IGH::FENDRR and KRAS mutations define a novel B-ALL subtype with 85% poor chemotherapy response.
- Open access
IDH2 mutations and IKAROS loss define a distinct subtype of lenalidomide-associated B-ALL, with IDH2 R140Q mutations enriched 23% in this condition.
- Open access
- 2 cites
The gut microbiota directs a three-day pathway of vitamin A derivatives from epithelial cells to T cells, shaping intestinal adaptive immunity.
- Open access
- 1 cites
Consensus guidelines for administering CAR T-cell therapy in adult B-ALL reached agreement on 33 key recommendations, guiding clinical practice amid limited randomized trials.
- Open access
The miR-15b/16-2 cluster acts as a tumor suppressor in T-cell acute lymphoblastic leukemia, impairing leukemic growth and progression by downregulating key oncogenes.
- Open access
Follow this area in the app
Browse JClub
Journals this month
- bioRxiv5569
- medRxiv1746
- Environ Res483
- PNAS463
- Sci Adv439
- JAMA255
- Cell Rep210
- BMJ199
- Nat Commun177
- Environ Pollution170
- Lancet149
- Science138
- NEJM119
- Applied & Environ Microbio116
- J Exp Bot115
- Curr Biol112
- mBio109
- Nature104
Moving areas, week to 3 Oct 2026
- Single-cell and spatial transcriptomics10
- Artificial Intelligence in Healthcare and Education8
- CAR-T cell therapy research7
- Neuroinflammation and Neurodegeneration Mechanisms6
- Lung Cancer Treatments and Mutations5
- Diabetes Treatment and Management4
- Pancreatic and Hepatic Oncology Research4
- Photosynthetic Processes and Mechanisms4
- Genomics and Chromatin Dynamics4
- Gut microbiota and health4