Consensus recommendations for CAR T-cell administration in adult acute lymphoblastic leukemia: a modified Delphi study.

Consensus guidelines for administering CAR T-cell therapy in adult B-ALL reached agreement on 33 key recommendations, guiding clinical practice amid limited randomized trials.

• Why it matters: Standardized treatment protocols are essential to optimize outcomes and manage toxicities in adult B-ALL patients receiving CAR T-cell therapy, addressing significant knowledge gaps.
• What they did: A modified Delphi study involving 36 expert investigators evaluated 58 statements on patient selection, treatment procedures, toxicity management, and post-therapy monitoring, achieving consensus on most.
• The result: The validated recommendations provide a structured framework for clinicians, improving consistency and safety in CAR T-cell therapy administration for adult B-ALL patients.