Applied & Environ MicrobioJClub
A switch-rheostat circuit governs quorum sensing homeostasis in a phytopathogen.
Applied and environmental microbiology · · Journal Article
Ristović, Bertani + more
Abstract ↗AI summary
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A promoter/intergenic pfsR-rsaM switch element in Pseudomonas fuscovaginae stringently represses the PfsI/R quorum sensing system, including both pfsR and rsaM expression.
- Why it matters: Unconventional AHL quorum sensing in this plant pathogen is inactive in laboratory conditions, and the role of the proposed RsaM regulator switch was unclear.
- What they did: The study shows repression of PfsI/R depends on the divergent pfsR-rsaM region rather than RsaM itself, and demonstrates endogenously expressed RsaM acts as a negative regulator.
- The result: The findings support a two-tier hierarchical repression model: a master repressor switch controls circuit activation, while RsaM modulates QS output after activation.
The findingWhy it mattersWhat they didThe result
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